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Download: The cable guy. The movie was directed by Jim Carrey, written by Michael Berg, and produced. While the movie is set in North America, many of the actions are.Plasma thromboxane B2: a biochemical marker of cerebrovascular resistance in severe head injury.
Increased vasospasm following traumatic injury of the brain has been reported. The mechanism(s) leading to this complication has yet to be determined. The objective of the present study was to examine the hypothesis that thromboxane (TX) generation may be increased as a consequence of ischemic and/or hemorrhagic injury to the brain and may contribute to the pathogenesis of cerebral vascular spasm. Plasma levels of TXB2, a stable metabolite of TXA2, were measured by radioimmunoassay in 40 patients with severe head injury at intervals from the time of injury to the fifth post-injury day. Plasma levels of TXB2 (mean +/- standard error) in the patients (578 +/- 137 ng/ml) were significantly higher (p less than 0.001) than normal values of TXB2 (247 +/- 40 ng/ml). Plasma TXB2 levels were significantly correlated with the presence of radiologic evidence of cerebral ischemia (44.7 +/- 9.1 ng/ml vs. 377 +/- 95.4 ng/ml; p less than 0.01) but not with duration of post-traumatic ischemia. These findings suggest that ischemic injury to the brain may be associated with increased generation of TXB2, a potent vasoconstrictor eicosanoid. The increased TXB2 levels may contribute to the spasm of cerebral arteries observed in severe head injuries.Post Profile
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