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Phata Poster Nikla Hero is a 2013 Bollywood masala film. The movie was produced by Ritesh Sidhwani and directed by Raaj Anand. The film is produced under the banner of Dimple Kapadia Productions. The story has been written by the director Raaj Anand and Sumeet Agarwal and the music has been composed by the duo Sajid-Wajid. .
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 .Treatment of malignant gliomas with an adenoviral vector encoding mutant thymidine kinase and ganciclovir.
The systemic toxicity associated with chemotherapy and radiotherapy for glioblastoma multiforme (GBM) limits dose escalation and can preclude resection in some patients. Expression of the cytotoxic nucleoside analog, ganciclovir (GCV), from the adenoviral vector Ad5.RSV.mTK-GCV has previously been demonstrated to selectively and regionally replicate in the tumor cells and maximize the expression of the therapeutic enzyme, herpes simplex virus (HSV)-thymidine kinase (TK), in order to maintain the activity of ganciclovir in the brain tumor environment. In this study, we investigated the dose-response profile of human U87-MG GBM cells exposed to the oncolytic adenoviral vector Ad5.RSV.mTK-GCV. Local replication and systemic toxicity were evaluated, and the anti-tumor efficacy of combination gene therapy was also assessed. Virus produced in the presence of increasing drug concentrations had an increased vector titer and intracellular drug concentration when compared to the free drug and drug carrier controls, respectively. Using bioluminescence imaging, we showed that the viral titers were sustained for several days, and a multilayer intratumor dose-response curve was obtained. The drug was effective when given systemically in addition to the intratumorally administered vector. When the therapy was administered at two separate time points, inhibition of tumor growth was significant at both times, but the inhibition was less pronounced than when the drug and virus were
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Google Ads Did a Shocking Media Slapdown of FiveThirtyEight’s Election Forecasts – gdubs
======
ChuckMcM
I’m not going to defend Google ads but I am going to defend the letter. It
says “not only has Google changed their election-related ads to avoid
influencing election-related content, but they have also refused to acknowledge
that Google Ads already targeted voters in a way that affects voting.”
And I’ve read the letter. What I can’t say for sure, but my guess is that
Google is hoping to ramp up its ‘information’ campaign to a new level at this
point. They have certainly found their target audience with the existing
advertisements, so I don’t blame them for going after the ‘big data’ crowd.
I don’t know if I agree with that one bit, but the effort they’ve made to
market that and other services suggests at least they have a strategy.
If people are upset that their political predictions are being influenced by
Google’s data collection then either change your prediction or try to
negotiate terms with Google, I don’t think there is anything wrong with
them…
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