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Although the prevalence of polypharmacy was low (2.9% of all patients), this fact shows the need for implementation of measures for appropriate polypharmacy in the geriatric population. Furthermore, this study suggested that some medications such as SSRIs are linked with a higher risk of adverse drug events, and that patients with polypharmacy might be a vulnerable group for exposure to anticholinergic and sedative medications. Our findings are compatible with the systematic review by Erkin and colleagues which reported that polypharmacy and high drug use are independently associated with adverse drug events [ 28 ]. The systematic review of Goncalves et al. found that polypharmacy itself is an independent risk factor for adverse drug reactions and drug-drug interactions. The authors also suggested that, in the presence of multiple medications prescribed, health care providers should consider the implications of polypharmacy, especially in patients with risk factors for medication errors [ 37 ].

An important finding of this study was the common co-prescription of inappropriate medications. The high rate of inappropriate co-prescriptions (Table 4) found in this study emphasizes the importance of minimizing the use of polypharmacy, as the guidelines suggest to avoid co-prescription of ≥ 5 medications [ 38 ]. Indeed, the five most commonly used inappropriate medications in the study were for the treatment of diabetes. However, due to the small number of patients exposed to polypharmacy, we were unable to estimate the actual prevalence of inappropriate co-prescription. A further limitation of our study is that the data used was not collected prospectively. Patients’ medications were collected at the time of their visit for face-to-face interview and were entered into the database immediately after the interview.




The researchers also found no association between the presence of different numbers of chronic diseases and the use of polypharmacy. This study found that about one-third of the patients surveyed had one or more chronic diseases, and only 12.7% were taking eight or more drugs. However, polypharmacy was most common among patients with only one chronic condition (35.2%) [ 26 ]. Antony et al. also reported that the number of medications used by women was higher than men (0.46 versus 0.41) [ 26 ]. These findings contradict those from our study as the number of medications prescribed to men was higher than women (0.30 versus 0.27). Only one previous study from Qatar was found in the literature, with the report documenting the polypharmacy rate in Qatar as 62.9% [ 28 ]. A limitation of the earlier study was that the estimate for polypharmacy and its association with NCDs were performed on a population of the elderly only, hence not including patients with certain NCDs like diabetes, CVDs, and dementia. As seen in Table 4, COPD is associated with the highest rate of polypharmacy (58.4%) in this study. This can be explained by the increased likelihood that COPD patients may be on medications to treat exacerbations. COPD is a chronic respiratory disease, classified as a group of disorders characterized by airflow limitation that is usually progressive and associated with an abnormal inflammatory response of the lungs to noxious particles or gases [ 29 ]. The prevalence of COPD increases with age and is higher in the elderly (up to 20% for people aged > 65 years) [ 29 ]. Several studies have suggested that the use of medication increases significantly with age [ 30 ]. 5ec8ef588b


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